Live animal experiments confirm that nasal drip of new crown vaccine can have immune effect

Science and Technology Daily, Beijing, August 25 (Intern Gao Xingjian) According to a recent report on the "Nature" website, through in vivo experiments on small laboratory animals, two groups of researchers in the United States and China have discovered that the infusion of candidate new crown vaccines in the nasal cavity can start To achieve the immune effect, and may be more effective than traditional injection vaccines, it is expected that after the vaccine is put into use, it can be provided to the public more efficiently, and its social benefits cannot be underestimated.

In order to implement the nasal vaccination experiment, a team from the University of Washington School of Medicine designed a candidate vaccine that can encode the spike protein of the new coronavirus. It is through this spike protein that the new coronavirus completes the infection process by binding to the host cell. The researchers injected the vaccine into mice that have the human receptor corresponding to the protein after bioengineering.

According to records and observations, after the injection of the vaccine, no infectious virus was found in the lungs of the mice exposed to the new coronavirus, but a small amount of viral RNA was indeed detected. In contrast, no viral RNA was detected in mice vaccinated nasally, combined with other evidence that nasal vaccination can achieve complete immunity.

At the same time, the research team of the First Affiliated Hospital of Guangzhou Medical University used another vaccine that encodes the spike protein of the new coronavirus to conduct experiments on rhesus monkeys. The researchers found that nasal vaccination is the same as traditional injection. Play the effect of preventing virus infection. At the end of the experiment, the trachea and bronchus of rhesus monkeys who received different doses of injection or nasal drops were sampled to detect viral nucleic acid at 9 sites, and the results were all negative. In contrast, monkeys that have not been vaccinated have detected high levels of virus in different locations.

The researchers said that the discovery of nasal vaccination methods can enable people to instill vaccines by themselves, which makes vaccination more convenient and easy. At the same time, the method of nasal immunization is expected to reduce the potential immune problems caused by the adenovirus vector itself and achieve better The immune effect.